Aplicación de HACCP para mejora de la calidad del arroz en Molino´s Cristo Morado S.A.C. Ferreñafe 2020

El presente proyecto tuvo como objeto aplicar un plan HACCP para mejorar la calidad de arroz en molinos cristo morado S.A.C., cuyo tipo y diseño de investigación fueron descriptivo y no experimental respectivamente. Asimismo, la información se recolectó mediante un cuestionario y guía documental. Con la herramienta de Ishikawa se establecieron las causas y se observó los agentes relevantes que se tienen que mejorar. Para aplicar la propuesta se utilizó un sistema documentario de técnicas y métodos que posibilitó trabajar de una forma más factible el proceso de pilado de arroz acrecentando su calidad esencialmente. Con esta propuesta la calidad de arroz mejoró en un 20%, además se logró un beneficio-costo de S/. 1.35, obteniendo el molino una utilidad de S/. 0.35 por cada sol que se invierte.TesisInfraestructura, Tecnología y Medio Ambient

Toward a conceptual framework for designing sustainable cyber-physical system architectures: A systematic mapping study

Cyber-physical systems (CPS) represent devices whose components enable interaction between machines and processes. One of the biggest challenges of these systems today is the ability to adjust to changes at the time of execution as they are implemented in environments with a multidimensional complexity, this challenge is currently addressed from the design of the systems themselves by integrating sustainability. With this problem in mind, the present document describes a systematic mapping study of the literature with the goal of demonstrating the current panorama of the frameworks, designs, and/or models used at the time of initiating the development of a cyber-physical system. As a result, it has been concluded that there is a lack of guidelines to construct sustainable, and evolvable cyber-physical systems. To address these issues, a framework for designing sustainable CPS architectures is outlined

Correlation between urban indices: The management of urban water use and urban marginalization

El presente artículo es producto de dos estudios; uno con un perfil de investigación aplicada, que considera la construcción de un sistema de indicadores para la valoración de la gestión del agua de uso urbano (IGSA); en cuarenta organismos operadores en México; la otra investigación, tiene carácter documental y, se realizó con datos publicados por el Consejo Nacional de Población (CONAPO), sobre el Índice de Marginación Urbana (IMU), en igual número de localidades. El propósito fundamental fue encontrar la correlación entre estas dos dimensiones. Se trabajó con la técnica estadística de correlación simple para comprobar de manera empírica afirmaciones de diferentes estudios que establecen que proveer de mejores servicios de agua a las comunidades, modifica de manera positiva su marginación urbana. Los resultados establecen una correlación inversa entre los indicadores, lo que se puede leer como que: a mayor índice de gestión del agua, es menor el grado de marginación en las ciudades. Se concluye que los beneficios al invertir en gestión del agua son mayores a los costos; presentando aproximaciones para entender porque se debe mejorar la gestión de los servicios del agua de uso urbana y, así mejorar la calidad de vida de habitantes de zona urbanas. This paper is the result of two studies. The first was applied research that involved the construction of a system of indicators to assess water management for urban use (IGSA) at forty utility providers in Mexico. The second study was documentary in nature and used data published by the National Population Council (CONAPO) on the Urban Marginalization Index (IMU), in an equal number of localities. The fundamental purpose was to find the correlation between these two dimensions. The statistical technique of simple correlation was used to empirically test affirmations from different studies that state that when better water services are provided to communities, urban marginalization is affected positively. The results show an inverse correlation between indicators, which can be interpreted as: the higher the rate of water management, the lower the level of marginalization in cities. It is concluded that the benefits of investing in water management outweigh the costs, and approaches are presented to understand why the management of water services for urban use should be improved, thereby improving quality of life for inhabitants of urban areas.

Actualización del servicio de ayuda a domicilio: necesidad y desafío. Una aproximación a las Comarcas de Valdejalón y Ribera Alta del Ebro

El trabajo que se presenta, además de profundizar en la implantación de la Ley de la Dependencia 39/2006, analiza cuál sería su aplicación en dos comarcas aragonesas: la Ribera Alta del Ebro y Valdejalón, proporcionando un catálogo de propuestas de actualización y mejora en sus servicios de ayuda a domicilio

High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. Future Perspectives for Factor V Deficiency Using Recombinant and Advanced Therapies

Enfermedad de Owren; Análisis de mutaciones; ParahemofiliaMalaltia d'Owren; Anàlisi de mutacions; ParahemofíliaOwren’s disease; Mutation analysis; ParahemophiliaFactor V is an essential clotting factor that plays a key role in the blood coagulation cascade on account of its procoagulant and anticoagulant activity. Eighty percent of circulating factor V is produced in the liver and the remaining 20% originates in the α-granules of platelets. In humans, the factor V gene is about 80 kb in size; it is located on chromosome 1q24.2, and its cDNA is 6914 bp in length. Furthermore, nearly 190 mutations have been reported in the gene. Factor V deficiency is an autosomal recessive coagulation disorder associated with mutations in the factor V gene. This hereditary coagulation disorder is clinically characterized by a heterogeneous spectrum of hemorrhagic manifestations ranging from mucosal or soft-tissue bleeds to potentially fatal hemorrhages. Current treatment of this condition consists in the administration of fresh frozen plasma and platelet concentrates. This article describes the cases of two patients with severe factor V deficiency, and of their parents. A high level of mutational heterogeneity of factor V gene was identified, nonsense mutations, frameshift mutations, missense changes, synonymous sequence variants and intronic changes. These findings prompted the identification of a new mutation in the human factor V gene, designated as Jaén-1, which is capable of altering the procoagulant function of factor V. In addition, an update is provided on the prospects for the treatment of factor V deficiency on the basis of yet-to-be-developed recombinant products or advanced gene and cell therapies that could potentially correct this hereditary disorder.This study was supported by the Andalusian Association of Hemophilia (ASANHEMO FV 2016–20 grant) and Octapharma S.A. (OCPH-2019-20 grant)

Reduced sTWEAK and Increased sCD163 Levels in HIVInfected Patients: Modulation by Antiretroviral Treatment, HIV Replication and HCV Co-Infection

Background: Patients infected with the human immunodeficiency virus (HIV) have an increased risk of cardiovascular disease due to increased inflammation and persistent immune activation. CD163 is a macrophage scavenger receptor that is involved in monocyte-macrophage activation in HIV-infected patients. CD163 interacts with TWEAK, a member of the TNF superfamily. Circulating levels of sTWEAK and sCD163 have been previously associated with cardiovascular disease, but no previous studies have fully analyzed their association with HIV. Objective: The aim of this study was to analyze circulating levels of sTWEAK and sCD163 as well as other known markers of inflammation (hsCRP, IL-6 and sTNFRII) and endothelial dysfunction (sVCAM-1 and ADMA) in 26 patients with HIV before and after 48 weeks of antiretroviral treatment (ART) and 23 healthy subjects. Results: Patients with HIV had reduced sTWEAK levels and increased sCD163, sVCAM-1, ADMA, hsCRP, IL-6 and sTNFRII plasma concentrations, as well as increased sCD163/sTWEAK ratio, compared with healthy subjects. Antiretroviral treatment significantly reduced the concentrations of sCD163, sVCAM-1, hsCRP and sTNFRII, although they remained elevated when compared with healthy subjects. Antiretroviral treatment had no effect on the concentrations of ADMA and sTWEAK, biomarkers associated with endothelial function. The use of protease inhibitors as part of antiretroviral therapy and the presence of HCV-HIV co-infection and/or active HIV replication attenuated the ART-mediated decrease in sCD163 plasma concentrations. Conclusion: HIV-infected patients showed a proatherogenic profile characterized by increased inflammatory, immuneactivation and endothelial-dysfunction biomarkers that partially improved after ART. HCV-HIV co-infection and/or active HIV replication enhanced immune activation despite ART.Redes Temáticas de Investigación en SIDA (ISCIII RETIC RD12/0017/0029 and RD12/0017/0037)Junta de Andalucía, Incentivos a proyectos de investigación de excelencia (CTS-6313, to Manolo Leal)Consejería de Salud (PI-0278)FIS PI10/00234 to LMBC and Programa Miguel Servet: CP10/00479 and PI13/00802 to JAMFundacion Lilly, FRIAT and ISCIII fund PI10/0007

PATRONES DE DIVERSIDAD DE EPÍFITAS EN BOSQUES DE TIERRAS BAJAS Y SUBANDINOS

Tropical rainforests are the most diverse ecosystems on the planet. Although many theories have been proposed to explain their richness we currently know little about their relative importance. This diversity is threatened by anthropogenic disturbances such as fragmentation and forest degradation. In this study we compared epiphytic plant diversity patterns in lowland and subandean forests. More epiphytic diversity was found in subandean (PNN Cueva de los Guácharos) compared to lowland forest (Palmarí Reserve). In addition a higher abundance of epiphytes was found in conserved forest. Tree host diversity was higher in lowland forests than in subandean forests, so we can reject the possibility that differences between the patterns of epiphytic diversity are caused by regional effects of plant diversity. Our results suggest that humidity seems to be the most important environmental filter explaining epiphyte diversity.Los bosques tropicales son los ecosistemas más diversos del planeta y aunque se han propuesto muchas teorías para explicar su riqueza, aún desconocemos gran parte de la importancia relativa de los factores que la afectan. Esta diversidad se encuentra amenazada por alteraciones de origen antrópico, como la fragmentación y la degradación de los bosques. En este estudio se comparan patrones de diversidad de epífitas en un bosque de tierras bajas y uno subandino. De esta manera, se encontró una mayor diversidad de epífitas en el bosque subandino (PNN Cueva de los Guacharos) comparado con el de tierras bajas (reserva Palmarí). Adicionalmente se encontró mayor abundancia de epífitas en los bosques más conservados. Dado que la diversidad de forofitos es mayor en el bosque de tierras bajas que en el subandino, se descarta la posibilidad de que las diferencias en los patrones encontrados se den por efectos regionales de diversidad de plantas. Se concluye que la humedad parece ser el filtro ambiental más importante para explicar la variación en diversidad de epífitas

Fluorescence Guided Surgery with 5-Aminolevulinic Acid for Resection of Spinal Cord Ependymomas

Study Design A retrospective study. Purpose We report our experience with 5-aminolevulinic acid (5-ALA)–assisted resection of spinal cord ependymomas in adults. Overview of Literature Ependymoma is the most frequent primary spinal cord tumor in adults. Surgery is the treatment of choice in most cases. However, while complete resection is achieved in approximately 80% of cases, clinical improvement is achieved in 15% only. Five-ALA fluorescence–guided surgery seems to be useful for this tumor type. Methods We studied 14 patients undergoing 5-ALA fluorescence-guided surgery for spinal cord ependymomas in our service. The modified McCormick classification was used to determine clinical status and the degree of resection was assessed with magnetic resonance imaging. Results Of the 14 patients, the tumor showed an intense emission of fluorescence in 12 and the fluorescence was weak and nonuniform in two. Complete resection was achieved in 11 cases. According to the McCormick classification, 10 patients improved, two remained the same, and two deteriorated. Conclusions Our results confirm that 5-ALA fluorescence-guided resection is useful in spinal cord ependymoma resection. Although the rate of complete resections is similar to that in published series without 5-ALA, clinical results are better when using 5-ALA with a lower percentage of clinical deterioration

Implementación De Servicios de Infraestructura It a Nivel de Intranet y Extranet Mediante Zentyal Server 6.2

Solucionada gran parte de las problemáticas de migración de los sistemas operativos, servicios y puesta en marcha de los sistemas de seguridad de la infraestructura de red, se entra en la fase final de la migración e implementación de los servicios solicitados. El trabajo final que cada estudiante debe desarrollar en esta fase, se orienta a la administración y control de una distribución GNU/Linux basada en Ubuntu, pero enfocada a la implementación de servicios de infraestructura IT de mayor nivel para Intranet y Extranet en instituciones complejas.Once a large part of the migration problems of the operating systems services and start-up of the network infrastructure security systems have been solved the final phase of migration and implementation of the requested services is entered. The final work that each student must develop in this phase is oriented to the administration and control of a GNU / Linux distribution based on Ubuntu but focused on the implementation of higher level IT infrastructure services for Intranet and Extranet in complex institutions

A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients

Type I interferonopathies are a heterogenic group of rare diseases associated with an increase in type I interferon (IFN). The main challenge for the study of Type I interferonopathies is the lack of a well-founded animal model to better characterize the phenotype as well as to perform fast and large drug screenings to offer the best treatment options. In this study, we report the development of a transgenic zebrafish model of Type I interferonopathy overexpressing ifih1 carrying the mutation p.Arg742His (Tg(ifih1_mut)), corresponding to the human mutation p.Arg779His. RNA sequence analysis from Tg(ifih1_mut) larvae revealed a systemic inflammation and IFN signature upon a suboptimal poly I:C induction compared with wild-type larvae, confirming the phenotype observed in patients suffering from Type I interferonopathies. More interestingly, the phenotype was manifested in the zebrafish inflammation and Type I IFN reporters nfkb:eGFP and isg15:eGFP, respectively, making this zebrafish model suitable for future high-throughput chemical screening (HTS). Using the unique advantages of the zebrafish model for gene editing, we have generated Tg(ifih1_mut) knocked down for mavs and ikbke, which completely abrogated the Poly I:C induction and activation of the GFP of the reporters. Finally, we used an FDA-approved drug, Baricitinib (Jak1/Jak2 inhibitor), which was able to reduce the inflammation and the ISG expression. Our results demonstrate the potential of this model to further understand AGS pathological mechanisms and to identify novel therapeutic drugs by HTS